By R. Felipe. Southwestern University School of Law.
Ultrasound shows a uterus that is enlarged for gestational age and is filled with multiple small generic aurogra 100mg otc impotence blood pressure, hyperechoic areas with good posterior acoustic enhancement order aurogra 100mg impotence caused by medication. During the first trimester cheap 100mg aurogra overnight delivery erectile dysfunction treatment in kl, the molar tissue may appear as a homogeneously echogenic endometrial mass. Hemorrhagic corpus Complex adnexal mass that may be associated with intraperitoneal blood if rupture has occurred. Corpus luteum cysts may be associated with early intrauterine pregnancies and elevated levels of human chorionic gonadotropin. The resulting interruption of arterial and venous circulation produces vascular engorgement in the ovarian parenchyma that may eventually lead to hemorrhagic infarction. Transverse sonogram shows a sac-like structure with no fetal pole (arrow) sonogram shows a second line (arrow) parallel to a portion in the uterus. Echogenic mass in the uterine cavity ovary (O) shows a complex cystic mass containing internal with multiple small, hyperechoic areas (arrowheads). Transverse scan shows a large complex adnexal mass (arrows) with a generally solid appearance. Degeneration or necrosis may result in decreased echogenicity and increased through- transmission of sound, sometimes simulating a cystlike mass. A subserosal leiomyoma attached to the uterus by a large stalk may occasionally simulate an adnexal mass or ovarian tumor. Although less than 2% of all leiomyomas undergo sarcomatous change, leiomyosarcoma is a not uncommon uterine tumor because of the frequency of leiomyomas. The tumor may be too small to be seen on ultrasound or may be indistinguishable from a benign leiomyoma. Unless evidence of local invasion can be demonstrated, the ultrasound findings are indistinguishable from those of fibroid tumors (which often occur in patients with endometrial carcinoma). Sagittal sonogram of the endometrial cavity (E) contains low-level echoes representing uterus (U) shows a small calcified focus (arrow) and blood. Ultrasound is of value in staging cervical carcinoma as it may detect thickening of parametrial or paracervical soft tissues, involvement of the pelvic side walls, extension into the bladder, and pelvic adenopathy. Sagittal sonogram shows a grossly dis- and a hypoechoic lesion in the uterine fundus (arrowhead). Transverse sonogram demonstrates a old girl shows a large pelvic mass (arrows) that extended to predominantly solid mass in the right adnexa (arrow). Sagittal scan shows a lobulated veals a soft-tissue mass with multiple cystic areas of varying mass containing both cystic and solid (arrowheads) sizes (arrowheads). Typically appears as a large, soft-tissue solid mass of placental (trophoblastic) tissue filling the uterine cavity and containing echoes of low to moderate amplitude. Numerous small cystic fluid- containing spaces are scattered throughout the lesion. Multiple larger sonolucent areas represent degeneration or internal hemorrhage in the molar tissue. Sagittal sonogram shows a uterine mass (M) containing irregular cystic areas (arrowheads) representing degeneration or internal hemorrhage in the molar tissue. On T1- Because it involves the myometrium diffusely, weighted images, no abnormality may be adenomyosis is a nonresectable condition that apparent. This distinction is critical, because a cavities (which have high signal intensity). In a septate uterus can be corrected easily in an bicornuate uterus, there is a deep external outpatient setting with transvaginal resection of notch in the fundus of the uterus and a thick or the septum. A bicornuate uterus is not always double medium-intensity band of myometrium repaired (but if it is, a laparotomy is required). Sagittal intense leiomyoma (L) almost completely surrounded by T2-weighted image shows two large subserosal endometrium. Measuring the depth of much as the surrounding myometrium and thus high-intensity tumor within the surrounding has low- or intermediate-signal intensity when hypointense myometrium can determine compared with the well-enhanced myometrium whether the invasion is superficial or deep. Myome- trial invasion can be detected as intermediate- signal tumor within the high-signal myometrium. Coronal T2-weighted image (A) and posterior (P) lips of the cervix and protruding through shows markedly diffuse enlargement of the junctional the external cervical os. Axial T2-weighted image at the hyperintense foci that are characteristic of this condition. An an accuracy rate for tumor staging higher than that intact ring of hypointense stroma surrounding of clinical palpation. In addition to demonstrating the lesion indicates that the tumor is confined extension into the pericervical and parametrial to the cervix. Axial T2-weighted image shows tal T2-weighted image shows tumor (t) causing segmental two uterine horns of similar size with functioning disruption of the junctional zone, with tumor confined to endometrium (E). Note the normal high-intensity enhancement of the posterior myometrium (open arrow). Coronal T2-weighted image through the cervix demonstrates a thin, intact, low-signal-intensity rim (arrows), representing residual cervical stroma surrounding the medium-signal- intensity tumor (T), which expands the cervix. Identification of this intact rim has high predictive value for excluding invasion into the parametrial and paracervical areas. The sacrum (S), iliac bones (i), and levator ani muscles (L) are labeled for orientation. Sagittal T2- weighted images show the high- intensity tumor (arrows) extending into the proximal vagina but not invading the bladder wall. Dermoid cyst Fatty component is isointense relative to Chemical shift imaging, fat suppression, and the (cystic teratoma) subcutaneous fat on all pulse sequences. Some are an adnexal mass as an endometrioma, this hyperintense on T1-weighted images and modality is not able to routinely identify small hypointense on T2-weighted studies. Therefore, laparoscopy are hyperintense on both sequences remains the primary procedure for the diagnosis (methemoglobin). Axial T2-weighted image shows demonstrates a well-defined homogeneous high-signal- two well-defined, homogeneous high-signal-intensity corpus intensity mass (arrows). Axial T2-weighted image shows an oval right ovarian mass containing a fat-fluid level (arrows). A diagnosis of malignancy can be made if the study identifies involvement of adjacent pelvic organs, intraperi- toneal metastases, retroperitoneal lymphadeno- pathy, or distant metastases. All three cysts are hyperintense (straight arrows, arrowhead), indicating that the adnexal mass is not due to fat as in a dermoid. Coronal T2-weighted image demo- nstrates bilateral ovarian enlargement (arrows) with rims of multiple, small high-intensity subcapsular follicles and abundant central stroma. Fibrothecoma Variable appearance depending on the relative Most common solid benign tumor of the ovary.
Patients who complain of presyncope will describe their symptoms as “lightheadedness” or “feeling like I’m going to black out cheap aurogra 100 mg amex impotence lotion. It is essential to differentiate vertigo from presyncope because vertigo is usually a manifestation of neurologic disease aurogra 100mg mastercard most popular erectile dysfunction pills, whereas presyncope is a cardinal manifestation of cardiovascular disease order aurogra online now impotence cure. Once you are convinced by the history that the patient is indeed experiencing vertigo, determine whether the vertigo is secondary to peripheral or central vestibular disease (management will differ). Central Vertigo Peripheral Vertigo Onset Gradual Usually sudden Tinnitus, hearing loss Absent Present Neighborhood signs (diplopia, cortical Present Absent blindness, dysarthria, extremity weakness/numbness) Nystagmus Pure, vertical, does not Mixed, horizontal, suppress with fixation, and suppresses with fixation, multidirectional and unidirectional Table 11-2. Vertigo Once you have determined that the patient has peripheral vertigo, there is a wide differential diagnosis that should be considered. Benign paroxysmal positional vertigo is a cause of peripheral vertigo that characteristically is exacerbated by head movement or change in head position. There will be a latency of several seconds after head movement before the onset of vertigo. Labyrinthitis presents with sudden onset of severe vertigo that lasts for several days with hearing loss and tinnitus. Perilymphatic fistula is a form of peripheral vertigo related temporally to head trauma (blunt trauma to the ear, e. Central vertigo is caused by any cerebellar or brain-stem tumor, bleed, or ischemia. Also, in the young patient with unexplained central vertigo, consider multiple sclerosis. Symptomatic treatment for peripheral vertigo includes meclizine or, in severe cases, diazepam. Benign paroxysmal positional vertigo is treated with positional maneuvers that attempt to move the otolith out of the circular canals (e. Vertigo secondary to labyrinthitis is treated symptomatically with meclizine and diazepam when the symptoms are severe. She locates her headache at the right side of her head and describes it as throbbing in quality. Primary headache syndromes include migraine (affecting 15% of the general population), cluster, and tension headache. Secondary causes of headache include intracranial hemorrhage, brain tumor, meningitis, temporal arteritis, and glaucoma. The single most important question to answer with a patient presenting with a complaint of headache is whether a serious underlying cause exists for the symptoms. By taking a thorough history and performing an adequate physical examination, it is possible to make this differentiation. Headache with fever and nuchal rigidity suggests meningitis as the underlying cause. Conversely, a headache described as “the worst headache of my life” and/or “thunderclap” at onset, and is accompanied by nuchal rigidity without fever, suggests an intracranial hemorrhage as the underlying cause. Patients with brain tumor will present complaining of headache that is described as a deep, dull, aching pain and disturbs sleep. A history of vomiting which precedes the onset of headache by a number of weeks, or a history of headache induced by coughing, lifting, or bending, is typical of posterior fossa brain tumor. Patients with temporal arteritis complain of a unilateral pounding headache associated with visual changes, described as dull and boring with superimposed lancinating pain. Their symptoms also include polymyalgia rheumatica, jaw claudication, fever, weight loss, and scalp tenderness (difficulty combing hair or lying on a pillow). Temporal arteritis gives an elevated sedimentation rate and is diagnosed with biopsy of the temporal artery. Patients with glaucoma will usually give a history of eye pain preceding the onset of the headache. Once serious underlying pathology is excluded by history and physical examination, primary headache syndromes should be considered. Migraine headaches are defined as a benign and recurrent syndrome of headache, nausea/vomiting, and other varying neurologic dysfunctions. Patients will describe the headache as pulsatile, throbbing, unilateral, and aggravated by minor movement. Other associated features include photophobia, phonophobia, and the time to maximal pain (4 to 72 hours). Typical triggers include alcohol, certain foods (such as chocolate, various cheeses, monosodium glutamate), hunger, or irregular sleep patterns. Migraine with aura (classic migraine) is a migraine accompanied by a preceding aura that consists of motor, sensory, or visual symptoms. Focal neurologic symptoms usually occur during the headache rather than as a prodrome. Migraine equivalent is defined as focal neurologic symptoms without the classic complaints of headache, nausea, and vomiting. Complicated migraine is migraine with severe neurologic deficits which persist after the resolution of pain. Basilar migraine is migraine associated with symptoms consistent with brain- stem involvement (vertigo, diplopia, ataxia, or dysarthria). Tension-type headaches are described as tight, band-like headaches that occur bilaterally. Patients may also describe their headache as “vise-like,” and these headaches may be associated with tightness of the posterior neck muscles. Patients will describe their pain as one that builds slowly, and the pain may persist for several days with or without fluctuations. Cluster headaches, common in men, begin without warning and are typically described as excruciating, unilateral, periorbital, and peaking in intensity within 5 minutes of onset. The attacks last from 30 minutes to 3 hours and occur 1–3× day for a 4-to-8-week period. Symptoms associated with cluster headaches include rhinorrhea, reddening of the eye, lacrimation, nasal stuffiness, nausea, and sensitivity to alcohol. Always begin with an attempt to identify probable triggers for the patient and to modify lifestyle by avoiding those triggers. Pharmacologic treatment for migraine headaches can be divided into management of an acute episode and prophylaxis. Acutely, abortive therapy consists of sumatriptan, which acts as a serotonin receptor agonist. The triptans are contraindicated in patients with known cardiovascular disease, uncontrolled hypertension, or pregnancy. In addition to sumatriptan, there is almotriptan, naratriptan, zolmitriptan, and eletriptan.
These usually lie between the posterior borders of the lobes of the thyroid gland and its capsule generic aurogra 100 mg without a prescription erectile dysfunction treatment fruits. Usually they are 4 in number discount 100 mg aurogra overnight delivery erectile dysfunction and premature ejaculation, two on each side and are called from their positions cheap 100 mg aurogra with visa impotence ka ilaj, the superior and inferior parathyroids. There is an anastomotic artery connecting the superior and inferior thyroid arteries and runs along the posterior border of the lobe of the thyroid gland. The superior parathyroid gland is more constant in position and is usually situated at the middle of the posterior border of the thyroid gland. Hie superior parathyroid glands are usually supplied by the anastomotic artery connecting the superior and inferior thyroid arteries while the inferior parathyroid glands are supplied by the inferior thyroid artery. Only occasionally the inferior parathyroids when they lie abnormally in the mediastinum may receive supply from thymic vessels, internal mammary vessels or rarely from the aorta. In children the gland consists of columns or cords of the principal cells (or chief cells). There are three varieties of chief cells according to the depth of staining — (a) dark chief cells, (b) light chief cells and (c) clear chief cells in which the cytoplasm is not easily stained. At about 10 years of age other cells appear — which are called oxyphil or eosinophil cells. The chief cells are concerned with secretion of parathormone, whereas the function of oxyphil cells is not known. The oxyphil cells are larger than the chief cells and contain more cytoplasm which stains deeply with eosin. The plasma calcium, normally about 10 mg/100 ml is partly bound to protein and partly diffusible. It is the free, ionized calcium which is necessary for coagulation, cardiac and skeletal muscle contraction and nerve function. Calcium in the bone is of two types — (i) readily exchangeable reservoir and (ii) stable calcium what is only slowly exchangeable. Excess dietary calcium is excreted in the stools, but most of the calcium liberated during bone resorption is excreted in the urine. In Vitamin D deficiency the protein matrix of new bone fails to mineralise producing rickets in children. In the kidney, this hormone decreases calcium clearance and causes increased excretion of phosphate in the urine. The latter action is due to inhibition of reabsorption of phosphate from the proximal convoluted portion of the renal tubule. Decrease in tubular reabsorption of phosphate causes phosphaturia and low plasma phosphate level. In the skeleton, parathyroid hormone promotes release of calcium from the bone by active transport process. It stimulates osteoclastic activity and may even convert osteoblasts to osteoclasts. In gastrointestinal tract, this hormone has a direct stimulatory effect on intestinal absorption of calcium. When the calcium level is high, secretion is diminished and calcium is deposited in the bones. When the calcium level is low, the secretion is increased and calcium is mobilized from the bones. There is no trophic hormone which influences the secretion of parathyroid hormone. In conditions such as chronic renal disease, in which the plasma calcium is chronically low, feed-back stimulation of the parathyroid glands causes compensatory parathyroid hypertrophy and secondary hyperparathyroidism. Multiple pancreatico duodenal neuroendocrine tumours causing Zollinger-Ellison syndrome in approximately 50% of cases which may be benign or malignant. There is also benign pituitary adenoma which may be functioning or non-functioning in 40% of cases which may cause acromegaly or cushing’s syndrome or there may be hyperplasia of the adrenal cortex and carcinoid tumour. Other associated disorders include thyroid neoplasms (adenoma or differentiated thyroid carcinoma), adrenal neoplasms and lipomas. In this case there is medullary carcinoma of the thyroid with pheocromocytoma and hyperparathyroidism. In type 2a hyperparathyroidism is seen in 25% of patients, whereas in type 2b there are additional neurofibromas affecting lips, eyelids and face producing swellings in these regions, megacolon and ganglioneuromatosis. Familial isolated hyperparathyroidism — is a rare autosomal dominant disorder, in which the risk of parathyroid carcinoma is about 20%. Parathyroid hyperplasia usually involves all 4 parathyroid glands, but the enlargement may be asymmetric. Parathyroid carcinomas are grey-white in appearance while hyperplasia is usually brown in colour. Thyroid cysts are extremely rare and occur from degenerative change in hyperplastic or adenomatous gland. The incidence increases with increasing age, though it may be seen between the ages of 20 and 60 years. The second group comprises the clinical features due to abnormal deposition of calcium in soft tissues. The third group comprises the effects of bone resorption and is seen in its most florid form in Von Recklinghausen’s disease. Deposition of calcium crystals on the renal tubules results in polyuria, dehydration, increased thirst and constipation. Calcification in the kidney is an important clinical manifestation of hyperparathyroidism. Stones may be formed in the renal tubules or in the calyces giving rise to renal or ureteric colic. When hyperparathyroidism is corrected, further stone formation is prevented, though pre-existing stones may need to be surgically removed. Calcium is laid down frequently in and around joint capsules and tendons of the lower limb. Calcium deposits may also be seen in blood vessels and symptomless calculi have been found in the pancreas and salivary glands. The degree of bony involvement varies so widely as to be undetectable in some patients while others have gross generalised cystic bone disease known as osteitis fibrosa cystica. If the disease is diagnosed at an early stage, radiological evidence of skeletal involvement may not be present. Backache, shoulder pain or generalised aches in the spinal region or limbs may be the early symptom of bone involvement. Bony tenderness may follow and sometime there are gross deformities such as kyphoscoliosis, obvious bony swellings and fractures. Radiological subperiosteal resorption of bone is the earliest and most consistent finding, which occurs especially in the middle phalanges of the index and middle fingers in the adult. Other bones commonly involved are the tibia, distal ulna, neck of femur, pubis and outer third of clavicle.
Volume-depleted patients present with signs of orthostatic or frank hypotension and tachycardia buy aurogra 100mg free shipping erectile dysfunction drugs forum. This demonstrates a reduction of effective arterial volume a physiologic term for perfusion of organs cheap aurogra 100mg with amex erectile dysfunction drugs in ghana, determined by intravascular volume buy aurogra 100 mg amex erectile dysfunction injection test, blood pressure, and cardiac output. Since the underlying physiology is systemic vasodilation, treatment with vasoconstrictors may be useful. This beneficial effect is most likely secondary to the decrease in intra-glomerular hypertension. This may come by obstruction of any part of the renal collection system (renal pelvises to urethra). Prostate: hyperplasia and cancer Neurologic disease: Neurogenic bladder: patients have a history of obstructive symptoms followed by sudden onset of oliguria or anuria. This may be due to multiple sclerosis, spinal cord lesions, or peripheral neuropathy. Clinical Presentation: Patients may experience a distended bladder in prostatism or neurologic disorders. Urine output may diminish or cease, proceeded by incomplete voiding in prostate or bladder diseases. The urinalysis is variable, from normal (neurogenic bladder) to hematuria (stones, bladder cancer, clots). Prostate or bladder outflow disease may be detected by finding large volumes of urine in the bladder after passing a Foley urinary catheter (a large post-void residual volume). After urinating (voiding), there should be no more than 50 mL of urine left in the bladder. If this post-void residual is markedly elevated, it implies an obstruction to the flow of urine out of the bladder. Treatment is based on quickly relieving the cause of the obstruction: For bladder/prostate disease, do Foley catheter insertion. For ureteral/pelvic obstruction, do nephrostomy tube insertion (percutaneous or transurethral). Clinical Recall Which of the following lab values is most likely in patients with prerenal azotemia? Causes include ischemia and hypoperfusion of the kidney (shock, sepsis, heart failure) and tubular toxins (aminoglycosides, contrast dyes, amphotericin, myoglobin [rhabdomyolysis], cisplatin). Next comes a reduction/cessation of urine flow (oligo- or anuria) as the tubules necrose and the glomerular ultrafiltrate back- leaks into the blood instead of forming urine. With severe or prolonged injury, the tubular cells will necrose and slough off into the urine and become visible as renal tubular epithelial cells or granular/muddy brown/pigmented casts. The rising serum creatinine (over days) is accompanied by reduced urine output or anuria. Treatment focuses on correcting the underlying cause (no therapy can reverse the renal failure). Volume repletion with normal saline is often given to make sure there is no prerenal component and may reduce contrast-induced renal failure, but it does not reverse it once it occurs. Dialysis may be needed if uremic symptoms occur, and is stopped once the tubules recover. Rhabdomyolysis can be caused either by (a) sudden/severe crush injury, seizures, or severe exertion, or (b) hypokalemia, hypophosphatemia, or medications (e. The toxicity is because the pigment is directly toxic to the tubular cells as well as from precipitation of the pigment in the tubules. The degree of toxicity is related to the duration of contact of the tubular cells with the hemoglobin or myoglobin, so is compounded by dehydration. Hyperuricemia due to release of purines from damaged muscles Treatment is normal saline to increase urine output and decrease toxin contact time. There is no test which can confirm a specific toxin as the etiology of the renal failure. Other causes of renal failure must first be excluded, and the toxin must be identified and promptly withdrawn. There is no specific therapy that can reverse the renal insufficiency of any direct-acting toxin. Aminoglycoside-related nephrotoxicity (10–20% of all drug-induced nephrotoxicity) is usually reversible. Unlike contrast dyes, aminoglycoside toxicity generally takes 5–10 days of administration to result in toxicity. Renal + failure due to aminoglycosides is frequently non-oliguric (so K levels are usually not elevated). Prevention is from limiting duration of use and by reducing trough levels by giving the antibiotic once a day. Once-a-day dosing allows high bactericidal levels with the same efficacy and very low trough levels. This antifungal agent is associated with renal insufficiency as well as distal renal tubular acidosis (non-anion gap metabolic acidosis with hypokalemia and high urine pH). Like aminoglycosides, it occurs only after several days or weeks of amphotericin use, and is usually reversible with prompt discontinuation of the drug. Unlike the antibiotics, radiocontrast used in radiology can result in renal failure in as little as 12–24 hours after the use of the agent. N-acetyl cysteine and sodium bicarbonate are often added but are of uncertain value. Uric acid toxicity occurs via intratubular crystallization, and usually occurs in the setting of tumor lysis syndrome after treatment of leukemias and lymphomas. Prevention is with vigorous hydration, sodium bicarbonate, and allopurinol prior to receiving chemotherapy. Allopurinol reduces the production of uric acid by inhibiting conversion of xanthine to hypoxanthine to uric acid. Uric acid stones precipitate in an acidic urine, unlike oxalate crystals, which precipitate in alkaline urine. Separately, gout may cause chronic kidney disease through a slower and milder version of intrarenal urate deposition. Diagnosis is confirmed with oxalate crystals seen on urinalysis (oxalate crystals are shaped like envelopes). Treatment is normal saline, sodium bicarbonate, and fomepizole to prevent the conversion of ethylene glycol to toxic oxalic acid. Separately, chronic hyperoxaluria and oxalate kidney stones can be caused by Crohn’s disease because of fat and calcium malabsorption. The urinalysis may be normal, since the dipstick does not detect the positively charged light chains. The etiology is usually an adverse immunologic effect to medications that commonly cause allergies (70% of cases). These include penicillin, cephalosporins, sulfa drugs, allopurinol, rifampin, and quinolones. Besides antibiotics, other examples of sulfa drugs are diuretics such as thiazides, furosemide, and acetazolamide.